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primary antibody against dsg2  (OriGene)


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    Structured Review

    OriGene primary antibody against dsg2
    Primary Antibody Against Dsg2, supplied by OriGene, used in various techniques. Bioz Stars score: 94/100, based on 7 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/primary+antibody+against+dsg2/pm42219531-292-43-47?v=OriGene
    Average 94 stars, based on 7 article reviews
    primary antibody against dsg2 - by Bioz Stars, 2026-08
    94/100 stars

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    DSG2 is up-regulated in human cervical cancer and is associated with a poor prognosis. ( A ) Higher expression of DSG2 was found in cervical cancer samples than the normal tissues (based on TCGA database). ( B ) Kaplan–Meier plots of overall survival for cervical cancer samples with high/low DSG2 expression from the TCGA database.

    Journal: Cancer Management and Research

    Article Title: DSG2 and c-MYC Interact to Regulate the Expression of ADAM17 and Promote the Development of Cervical Cancer

    doi: 10.2147/CMAR.S456548

    Figure Lengend Snippet: DSG2 is up-regulated in human cervical cancer and is associated with a poor prognosis. ( A ) Higher expression of DSG2 was found in cervical cancer samples than the normal tissues (based on TCGA database). ( B ) Kaplan–Meier plots of overall survival for cervical cancer samples with high/low DSG2 expression from the TCGA database.

    Article Snippet: Primary antibodies against DSG2 (21,880-1-AP, 1:1000, Proteintech), ADAM17 (29,948-1-AP, 1:2000, Proteintech) and c-MYC (67,447-1-Ig, 1:5000, Proteintech) were used.

    Techniques: Expressing

    Knockdown of DSG2 in cervical cancer cells. ( A ) The knockdown efficiency of the three groups of siRNA in HeLa cells was 84%, 86% and 28%, respectively. ( B and C ) The specificity and validity of the siRNA knockdown of DSG2 expression in HeLa and SiHa cells was verified by qPCR ( B ) and WB ( C ). *P < 0.05, **P < 0.01.

    Journal: Cancer Management and Research

    Article Title: DSG2 and c-MYC Interact to Regulate the Expression of ADAM17 and Promote the Development of Cervical Cancer

    doi: 10.2147/CMAR.S456548

    Figure Lengend Snippet: Knockdown of DSG2 in cervical cancer cells. ( A ) The knockdown efficiency of the three groups of siRNA in HeLa cells was 84%, 86% and 28%, respectively. ( B and C ) The specificity and validity of the siRNA knockdown of DSG2 expression in HeLa and SiHa cells was verified by qPCR ( B ) and WB ( C ). *P < 0.05, **P < 0.01.

    Article Snippet: Primary antibodies against DSG2 (21,880-1-AP, 1:1000, Proteintech), ADAM17 (29,948-1-AP, 1:2000, Proteintech) and c-MYC (67,447-1-Ig, 1:5000, Proteintech) were used.

    Techniques: Knockdown, Expressing

    Knockdown of DSG2 inhibited proliferation and migration of cervical cancer cells. ( A ) The proliferation of HeLa and SiHa cells after knockdown of DSG2 was measured using CCK-8 assay. ( B ) The effect of DSG2 knockdown on cervical cancer cell clone formation. ( C ) The migration ability of HeLa and SiHa cells after knockdown of DSG2 was measured using Transwell assay. *P < 0.05, **P < 0.01, ***P < 0.001.

    Journal: Cancer Management and Research

    Article Title: DSG2 and c-MYC Interact to Regulate the Expression of ADAM17 and Promote the Development of Cervical Cancer

    doi: 10.2147/CMAR.S456548

    Figure Lengend Snippet: Knockdown of DSG2 inhibited proliferation and migration of cervical cancer cells. ( A ) The proliferation of HeLa and SiHa cells after knockdown of DSG2 was measured using CCK-8 assay. ( B ) The effect of DSG2 knockdown on cervical cancer cell clone formation. ( C ) The migration ability of HeLa and SiHa cells after knockdown of DSG2 was measured using Transwell assay. *P < 0.05, **P < 0.01, ***P < 0.001.

    Article Snippet: Primary antibodies against DSG2 (21,880-1-AP, 1:1000, Proteintech), ADAM17 (29,948-1-AP, 1:2000, Proteintech) and c-MYC (67,447-1-Ig, 1:5000, Proteintech) were used.

    Techniques: Knockdown, Migration, CCK-8 Assay, Transwell Assay

    ADAM17 is up-regulated in human cervical cancer and is associated with a poor prognosis. ( A ) The bioinformatics analysis of TCGA-CHOL dataset showed the positive expression correlation between DSG2 and ADAM17. ( B ) Higher expression of ADAM17 was found in cervical cancer samples than the normal tissues (based on TCGA database). ( C ) Kaplan–Meier plots of overall survival for cervical cancer samples with high/low ADAM17 expression from the TCGA database.

    Journal: Cancer Management and Research

    Article Title: DSG2 and c-MYC Interact to Regulate the Expression of ADAM17 and Promote the Development of Cervical Cancer

    doi: 10.2147/CMAR.S456548

    Figure Lengend Snippet: ADAM17 is up-regulated in human cervical cancer and is associated with a poor prognosis. ( A ) The bioinformatics analysis of TCGA-CHOL dataset showed the positive expression correlation between DSG2 and ADAM17. ( B ) Higher expression of ADAM17 was found in cervical cancer samples than the normal tissues (based on TCGA database). ( C ) Kaplan–Meier plots of overall survival for cervical cancer samples with high/low ADAM17 expression from the TCGA database.

    Article Snippet: Primary antibodies against DSG2 (21,880-1-AP, 1:1000, Proteintech), ADAM17 (29,948-1-AP, 1:2000, Proteintech) and c-MYC (67,447-1-Ig, 1:5000, Proteintech) were used.

    Techniques: Expressing

    DSG2 regulates the expression of ADAM17 in cervical cancer. ( A ) The effect of DSG2 knockdown on ADAM17mRNA expression was detected by qPCR. ( B ) The effect of DSG2 knockdown on ADAM17 protein expression was detected by WB. ( C ) The interaction between DSG2 and c-MYC was detected by Co-IP assay. ***P < 0.001.

    Journal: Cancer Management and Research

    Article Title: DSG2 and c-MYC Interact to Regulate the Expression of ADAM17 and Promote the Development of Cervical Cancer

    doi: 10.2147/CMAR.S456548

    Figure Lengend Snippet: DSG2 regulates the expression of ADAM17 in cervical cancer. ( A ) The effect of DSG2 knockdown on ADAM17mRNA expression was detected by qPCR. ( B ) The effect of DSG2 knockdown on ADAM17 protein expression was detected by WB. ( C ) The interaction between DSG2 and c-MYC was detected by Co-IP assay. ***P < 0.001.

    Article Snippet: Primary antibodies against DSG2 (21,880-1-AP, 1:1000, Proteintech), ADAM17 (29,948-1-AP, 1:2000, Proteintech) and c-MYC (67,447-1-Ig, 1:5000, Proteintech) were used.

    Techniques: Expressing, Knockdown, Co-Immunoprecipitation Assay

    DSG2 regulates cervical cancer development by interacting with c-MYC. ( A ) HeLa cells were transfected with pcDNA(3.1)-DSG2 overexpression plasmid, and the mRNA level of DSG2 was detected by qPCR. ( B ) HeLa cells were transfected with pcDNA(3.1) overexpression plasmid, and the protein level of DSG2 was detected by WB. ( C and D ) DSG2 overexpressed HeLa cells were treated with a C-MYC inhibitor (10,058-F4, 50 μM), and the proliferative activity and migration ability were detected by CCK-8 ( C ) and clonal formation assay ( D ). ( E ) DSG2 overexpressed HeLa cells were treated with a C-MYC inhibitor, and ADAM17 protein expression was detected by WB.*P < 0.05, **P < 0.01, ***P < 0.001.

    Journal: Cancer Management and Research

    Article Title: DSG2 and c-MYC Interact to Regulate the Expression of ADAM17 and Promote the Development of Cervical Cancer

    doi: 10.2147/CMAR.S456548

    Figure Lengend Snippet: DSG2 regulates cervical cancer development by interacting with c-MYC. ( A ) HeLa cells were transfected with pcDNA(3.1)-DSG2 overexpression plasmid, and the mRNA level of DSG2 was detected by qPCR. ( B ) HeLa cells were transfected with pcDNA(3.1) overexpression plasmid, and the protein level of DSG2 was detected by WB. ( C and D ) DSG2 overexpressed HeLa cells were treated with a C-MYC inhibitor (10,058-F4, 50 μM), and the proliferative activity and migration ability were detected by CCK-8 ( C ) and clonal formation assay ( D ). ( E ) DSG2 overexpressed HeLa cells were treated with a C-MYC inhibitor, and ADAM17 protein expression was detected by WB.*P < 0.05, **P < 0.01, ***P < 0.001.

    Article Snippet: Primary antibodies against DSG2 (21,880-1-AP, 1:1000, Proteintech), ADAM17 (29,948-1-AP, 1:2000, Proteintech) and c-MYC (67,447-1-Ig, 1:5000, Proteintech) were used.

    Techniques: Transfection, Over Expression, Plasmid Preparation, Activity Assay, Migration, CCK-8 Assay, Tube Formation Assay, Expressing